Pax proteins (called Paired box protein) regulate processes related to the division and differentiation of many cell types during embryonic and postnatal development in different animal species. Pax genes are evolutionarily conserved, their homologs found in the genome of nematodes and insects, and amphibians, fish, birds and mammals. No genes or functional abnormalities of the Pax proteins can lead to malignant transformation. In this paper, the structure and functions of Pax factors and their interaction with other proteins.

Proteolysis of protein on the cell surface and extracellular matrix proteolysis is a very important process that occurs in cells functioning properly. ADAM metalloproteinases are transmembrane proteins that combine features of adhesion molecules and proteinases. These proteins are involved in adhesion, fusion, release of extracellular domains of transmembrane proteins, signal transduction. ADAM proteins play an important role in processes related to: fertilization, myoblast fusion, neurogenesis, and many other processes.