Nuclear receptors Nur77 , NURR1 and NOR -1 belong to the family of Nur77 and the steroid receptor superfamily - thyroid . These proteins are involved in the processes of thymocyte apoptosis , differentiation of nerve cells , the production of steroid hormones. Influence on these processes for therapeutic purposes requires the knowledge of mechanisms of regulation of expression and function of Nur77 family proteins and their role in various signaling pathways . Nur77 expression and function is regulated at the level of gene transcription and protein phosphorylation .