Lamins are components of nucleus, which not only influence organization and integrity of nuclear envelope, but are also essential for the maintenance and processing of genetic material. Therefore, disturbance of their functioning as a result of mutations in various regions of the protein molecule can have serious consequences for the number and activity of cells in various tissues. Since identifying lamin defects as important factors in a vast range of diseases, research aimed at elucidation of tissue-specific mechanisms in the pathophysiology of particular syndroms has been in progress.

Protrusion of the leading edge represents the first step of cell migration. This process is connected with formation of cytoskeletal actin-containing structures called lamellipodia and filopodia. Reorganization of cortical actin filaments in response to extracellular stimuli is controlled by The Wiskott- Aldrich syndrome proteins (WASP), a protein family members that are believed to be important effectors of Rho GTPases and to mediate in activating Arp2/3 (actin-related protein 2-3) complex.

Expression and function of the receptors, the LH / hCG in tissues of man and pig pozagonadowych