DNA repair in mammalian cell

Chronic , excessive alcohol consumption entails structural changes in the liver , brain and other organs , and is associated with an increased risk of developing certain types of cancer. Ethanol metabolism leads to the formation of acetaldehyde and acetic acid. Acetaldehyde adducts with DNA and proteins , reduces the efficiency of DNA repair systems and also reduces the level of glutathione , a peptide involved in detoxification . When ethanol metabolism by cytochromes and by alcohol dehydrogenase and xanthine oxidase as free radicals.

DNA damage due to the origin divided into endogenous , linked to the activity of endogenous cellular processes and exogenous . For the cellular processes responsible for changes in the genetic material primarily involve electron transport in the respiratory chain , enzymatic reactions involving oxidases and cytochromes , the redox cycles , inflammatory processes . Interest continues to grow exogenous factors due to the risk associated with their presence in the environment , food, possibility of use in the treatment of cancer and other diseases .