Sperm antigens may provoke iso-and autoimmune diseases. It is therefore important to identify and to isolate sperm autoantigens specifically reacting with the antibodies. This may not only have a learning value, but also be applied to control reproduction. This article describes the known autoantigens sperm present both on the surface and inside the cell. It also presents the results of studies describing attempts to sensitize and utility of laboratory animals to induce infertility.