GnRH (GnRH) is a key regulator of the expression of specific genes encoding three gonadotropin subunits (?, LH? And FSHb) in the pituitary. The promoter of the gene protein LHb SF-​​1, EGR-1 and SP-1 to form a complex, three-part regulatory element responsible for full activation of transcription of the gene by GnRH. The position -443 promoter sequence identified CCATTTTTGG (called CArG box) responsible for gene activation by pulsed LHb released GnRH. Dependent upon the specific GnRH-subunit gene expression is associated with activation while two protein binding sites on the promoter ETS.