One of the immune surveillance mechanisms to protect the human body against the development of cancer is the presence of monoclonal IgM natural antibodies in the circulation. Routine immunosuppression is a wonderful occasion to carcinogenesis. Such a situation occurs for example after viral infections or is caused by smoking cigarettes. In addition, a growing cancer induces immunological tolerance. The possibility of using immunotherapy to treat cancer involves: a reduction of tumor cell mass, e.g., by the use of specific monoclonal antibodies, and to increase the number of specific cytotoxic T cell clones corresponding vaccination.