Simulated annealing is a calculation method used in both the process of solving the structures of biomolecules , as well as in the modeling of the structure and dynamics of these compounds. This method is a variant of molecular dynamics and as such it involves a classic treatment of the atoms in the system under study . Apply here for additional techniques for better penetration of the system configuration , including increasing the temperature . The influence of amino acid change in the structure of antytrypsynie its microenvironment and the dynamics of the whole protein molecule . It also provides examples of the use of this method in drug design . Discusses the advantages and disadvantages of the method and indicated for other uses, such as simulation of protein folding . The work is based on the results of their own and literature data mainly from the last ten years, and which illustrate the new trends in the field of simulation of proteins by computer simulation.