The role of receptor peroxisome proliferator-activated gamma (PPARg) in Adipogenesis, obesity and type 2 diabetes

The fat tissue is very dynamic , and as a result of hyperplasia , which is a consequence of the proliferation and differentiation of preadipocytes may contribute to the development of obesity. This process is regulated by a complex number of specific genes. Among them, certainly deserves attention PPARg receptor whose expression is noted particularly strong in adipose tissue . It is a key factor in the adipogenesis process and is responsible for the differentiation of preadipocytes into mature cells called adipocytes . In addition , it regulates lipid metabolism in adipose tissue .

Transcriptional regulation of adipogenesis

The main role of adipocytes is to store triacylglycerol in periods of energy excess and its reserves at the time of energy shortages. These cells act also secretory synthesize many paracrine and endocrine, among others. leptin. Adipogenesis is a multistep process for converting the primordial germ cells and preadipocytes into mature adipocytes. This process is controlled by several genes, particularly PPAR and C / EBP. The polymorphism of these genes may affect the development of obesity in humans and livestock characteristics of fat.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

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