Endothelial Progenitor Cells: origin, characteristics and prospects of use in therapy

Vascular endothelium and the blood cells are derived from mesodermal cells of the common hemangioblastu. The confirmation of the close relationship of both cell lines are common antigens, occurring in the early stages of differentiation. Endothelial precursor cells, defined as CD34 + CD133 + Flk-1 +, can be differentiated in vitro cultured endothelial cells. Progenitors of endothelial cells, isolated from bone marrow, cord blood and peripheral blood in vivo may incorporate into the vessel wall and damaged endothelial function to take.

Cerebral capillaries. Ultrastructural markers of angiogenesis

The article describes the morphological characteristics of capillaries around the brain barrier and barrier. Also shown at the ultrastructural level nowoformowanych vascular examples, which are formed by two different mechanisms, and with the participation of endothelial stem cells. Morphological observations are confirmed by immunocytochemistry studies.

Endothelial nitric oxide synthase Vol. II. biological Function

Disorders of eNOS expression and activity are combined with disease entities such as atherosclerosis , coronary heart disease , hypercholesterolemia and hypertension . The first time was identified eNOS in endothelial cells of veins and arteries ; More detailed studies have shown the presence of this enzyme in myocytes , platelets, and neurons Leydig and Sertoli cells . Endothelial nitric oxide synthase accumulates inwaginacji at specific sites of the cell membrane .

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email:

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