Basics topics: cellular DNA is continuously damaged ; activity of cell cycle checkpoint is a part of the cellular response to DNA damage. 1 The control system of the genome and the passage through the cell cycle As you study the regulation of the cell cycle regulatory mechanisms discovered ties with a complicated network of signaling pathways , which is called the system of supervising the genome. 2 The cellular response to DNA damage .

The correct sequence of events in the cell cycle progression is monitored by a complex molecular mechanism , wherein the anchor points serve as signal transduction pathways , both operated upon detection of disturbances in the assembly of cellular structures , and in the normal course of subsequent stages of interphase and mitosis. The system of these points in time starts and stops the key enzymes controlling the cell cycle , and any signals of structural disruption or damage following reactions converts blocking DNA synthesis or by inhibiting the initiation of cell division.

Presented scientific silhouettes awarded the 2001 Nobel Prize in physiology and medicine ? Leland Hartwell , Paul Nurse'a and Timothy Hunt , the pioneers of molecular mechanisms regulating the cell cycle . Their research mainly due to the detection of protein serine- threonine kinases called cyklinozależnymi , due to the regulation of their activity by specific protein ? cyclins . These kinases subsequently proved to be essential for normal cell cycle progression . Classic has become the concepts introduced by Hartwell START cycle checkpoints .