FIND ARTICLE

IMMUNOLOGICAL SYNAPSES AND THEIR ROLE IN EFFECTOR MECHANISMS OF THE IMMUNE SYSTEM

T cells and antigen presenting cells (APC) form a specialized cell-cell junction termed the immunological synapse (IS). It is characterized by a central region of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. This minireview discusses the current knowledge on the formation, function and diversity of immunological synapses. Cytoskeletal remodeling in T cells, which is connected with signals delivered by costimulatory molecules, plays a crucial role in a formation of IS.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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