Participation of the complement system in the regulation of hematopoiesis

The paper presents experimental data showing that the complement system plays an important, underestimated so far a role in regulating hematopoiesis. Activation products of the complement C3 fragment governs the response of early hematopoietic cells to a gradient of SDF-1, which is the main stem cell chemoattractant. The complement system is activated in the bone marrow, both in the preparation myeloablative transplantation of hematopoietic cells before and during their pharmacologically induced mobilization from the bone marrow to peripheral blood.

Preliminary assessment of the possible use of hematopoietic stem cells obtained from different donor umbilical cord blood transplantation for simultaneous Adult Recipients

The primary disadvantage of cord blood as a source of cells for transplantation , the number of cells is small , usually less than 1 billion times, allowing operation only in children under 30 kg , while the majority of recipients has a larger weight. Hence the idea of simultaneous use of several units of cord blood , which together are designed to provide a sufficient number of cells for transplantation to an adult recipient. The bottom line is that the immune cells in cord blood , as young cells should not be able to cross- reactions against each other.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

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