FIND ARTICLE

BIOLOGICAL ROLE OF microRNA (miRNA) NEW DATA

MicroRNA (miRNA) is a group of small, 2123-nucleotide-long, non-encoding RNA particles, which in the mature form regulate gene expression at the post-transcription level. Presently, over 3000 miRNAs are known, described in vertebrates and insects, but also in plants, fungi, unicellular organism and viruses. In the human genome, so far over 470 miRNAs have been discovered, although it is assumed that there are about 1000.

THE FACTORS OF NEGATIVE REGULATION OF TLR (TOLL-LIKE RECEPTORS)

In the paper five groups of factors (soluble forms of TLRs, intracellular regulators, transmem- brane regulators, reduction of TLR expression and reduction of TLR effect) of negative regulation of TLRs (Toll-like receptors) have been described.

HUMAN CYTOMEGALOVIRUS (HCMV) –LATENCY AND IMMUNE EVASION

Human cytomegalovirus (HCMV) has ability to lifelong maintenance within the host using mechanisms involved in latency. Virus can reactivate and during reactivation HCMV uses different mechanisms (inhibition of antigen presentation, influence on cytokine network, inhibition of NK cells, disturbance of apoptosis) which downregulate effectiveness of immune cells.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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