STAT mediators comprise a family of seven proteins, that play a key role in intracellular signaling. They are involved in cell differentiation, proliferation and cell death. This article presents a description of STAT proteins with a focus on their probable role in pathology of alimentary system, particularly inflammatory bowel disease and colon carcinogenesis. In inflammatory bowel disease action of STAT3, STAT1, STAT 4 predominates. STAT1 and STAT3 play remarkable roles in colon carcinoma. It was discovered that STAT1 blocks cell proliferation in cell lines of colorectal cancer.