Matrix metalloproteinase (MMP) family consists of Zn2+-dependent endopeptidases. The enzymes degrade structural proteins of basement membranes and extracellular matrix facilitating tissue remodeling and cell mobility thus phenomena accompanying physiological and inflammatory processes as well as cancer diseases. One of the subgroups among MMPs is a subfamily of gelatinases consisting of gelatinase A (MMP-2) and gelatinase B (MMP-9).