FIND ARTICLE

THE PROTO-ONCOGENE BCL-6 EXPRESSION IN NORMAL AND MALIGNANT B CELLS

The human proto-oncogene BCL-6, encodes transcriptional repressor that is necessary for germinal-center formation, T cell dependent antibody responses, regulation of B cell differentiation, and B-cell receptor signaling modulation. High expression of BCL6 is detected in GC B cells, but not in pre-GC B cells or in more differentiated memory or plasma cells. It performs a function as a potent transcriptional repressor of various target genes, but the precise function of BCL6 in these processes is unclear.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

PBK Postępby biologi komórki