The human proto-oncogene BCL-6, encodes transcriptional repressor that is necessary for germinal-center formation, T cell dependent antibody responses, regulation of B cell differentiation, and B-cell receptor signaling modulation. High expression of BCL6 is detected in GC B cells, but not in pre-GC B cells or in more differentiated memory or plasma cells. It performs a function as a potent transcriptional repressor of various target genes, but the precise function of BCL6 in these processes is unclear.