Every human organ has its own capacity for self renewal due to progenitor cells of tissue reservoir. We can distinguish organs with 'high and low turnover' and for regenerative medicine the latter ones constitute the main target. These are represented by heart, central nervous system and pancreas. In this review, we focused on determination in situ of stem cell function in described organs and tissues. However, even in 'low turnover' systems the level of stem cell homing can be different. Surprisingly it is in favour of central nervous system.