The role of receptor peroxisome proliferator-activated gamma (PPARg) in Adipogenesis, obesity and type 2 diabetes

The fat tissue is very dynamic , and as a result of hyperplasia , which is a consequence of the proliferation and differentiation of preadipocytes may contribute to the development of obesity. This process is regulated by a complex number of specific genes. Among them, certainly deserves attention PPARg receptor whose expression is noted particularly strong in adipose tissue . It is a key factor in the adipogenesis process and is responsible for the differentiation of preadipocytes into mature cells called adipocytes . In addition , it regulates lipid metabolism in adipose tissue .

Beacon - biologically active peptide associated with the occurrence of obesity

Beacon (BC ) is a newly discovered peptide isolated from the hypothalamus piaskówki ( Psammomys obesus) , which has been implicated in the regulation of energy balance. It is also known under the names of ubiquitin -like protein 5 ( UBL5 ) and homologous to ubiquitin ( Hub 1 ) . His presence is observed in almost all tissues examined . Beacon gene is highly conserved interspecies . Its expression in the hypothalamus, is proportional to glucose and insulin levels and body fat percentage and body mass in an animal species Psammomys obesus .

The impact of obesity and age on the results of ovulation induction

Stimulation of ovulation is a very important step in the whole process of infertility treatment . The primary objective is to obtain one or more normal oocytes. The effects of treatment may be dependent on many different factors. The most frequently mentioned , and whose importance for the results of stimulation is still under discussion , please obesity and age. Obesity can be a symptom of an existing endocrinopathies ( PCO syndrome ) or inadequate nutrition. In obese women are more often observed ovulation disorders associated with the secretion , transport and metabolism of hormones.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
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