FIND ARTICLE

The role of thiols in platelet activation

Thiol compounds present in the cells can be divided into low molecular weight and protein . Protein thiol groups , derived from cysteine ​​, may be present as free thiols, disulfides and mixed disulfides in combination with a low molecular weight thiols : glutathione , cysteine ​​, homocysteine ​​, and ? - Glutamylocysteiną . Metabolic related reactions of thiols have an important role in platelet function , anucleate cells derived from megakaryocytes , and performing an important role in hemostasis .

Interactions of platelets with endothelial cells in inflammatory Part II. Substances released from platelets - regulating the signal transduction pathways in endothelial cells in inflammation

Megakaryocytes from them , and the resultant platelet synthesize many pro-inflammatory and pro - atherosclerotic lesions. These mediators are stored in a platelet granules . Platelet activation induces the release of mediators in the extracellular environment . Resting platelets do not adhere to unstimulated endothelial cells and do not react with them and with the vessel wall . Activation of endothelial cells and / or platelets triggers the inflammation, which causes inter alia atherosclerosis .

Interactions of platelets with endothelial cells in inflammatory Part I. platelet adhesion receptors, endothelial cells, and micro-bubbles in hemostasis and inflammation

The most important function of blood platelets is involved in primary hemostasis comprising forming the stud part in the hemostatic and secondary hemostasis , or clotting factor activation and production of thrombin. Platelets are also involved in many physiological and pathological processes , including in wound healing , defense against bacterial infections , metastasis of tumor cells and the formation and development of inflammation and atherosclerosis . Resting platelets do not adhere to unstimulated endothelial cells and do not react with the wall of the blood vessel.

The role of reactive oxygen species in platelets

Reactive oxygen species ( ROS) , which include superoxide anion ( O2. ) , hydroxyl radical (OH) , hydrogen peroxide (H2O2) , singlet oxygen ( 1O2 ) and nitric oxide (NO) are highly reactive particles. Can react with lipids, proteins or DNA , causing irreversible changes in the structure of these compounds. Platelets , like other cells , can generate ROS , which are drawn into the mechanisms of activation of these cells . There are several ways to manufacture platelet RFT .

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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