The paper presents a brief overview of how to describe the effects of the polar environment in the molecular dynamics simulations bioukładów. Discussed in greater detail: (1) scaling electrostatic interactions, (2) the potential of solvation, (3) the effect of polarization of the solvent, and (4) inclusion of explicit water molecules. Given the theoretical basis for methods and possible areas of applications. The sequence corresponds to discuss methods of increasing complexity in parallel with their computational demands.