The paper presents the most important aspects of the in vitro differentiation of precursor cells isolated from adipose tissue in a direction from the mesoderm, as well as endo-and ectoderm wide showing their potential to repair damaged tissues. Thanks to their characteristics, these cells may find use in tissue engineering and cell therapy.

The fat tissue is very dynamic , and as a result of hyperplasia , which is a consequence of the proliferation and differentiation of preadipocytes may contribute to the development of obesity. This process is regulated by a complex number of specific genes. Among them, certainly deserves attention PPARg receptor whose expression is noted particularly strong in adipose tissue . It is a key factor in the adipogenesis process and is responsible for the differentiation of preadipocytes into mature cells called adipocytes . In addition , it regulates lipid metabolism in adipose tissue .

TNF-a plays a key role in physiological and pathological mechanisms regulating energy metabolism in the body. The paper presents the current views of TNF-a on lipid metabolism. The role of cytokines in the biosynthesis of PAI-1, leptin and insulin formation.