FIND ARTICLE

THIOREDOXIN-THIOREDOXIN REDUCTASE SYSTEM – A NOVEL TARGET FOR ANTITUMOR THERAPY

A bulk of biochemical pathways, which play a crucial role in such processes as protection of cells from oxidative stress, cellular proliferation or selenium metabolism are regulated by thioredoxin - thioredoxin reductase system. This system consists of two groups of enzymatic proteins which require NADPH for their activity. NADPH is acquired mainly from pentose phosphate pathway. Proteins from thioredoxin family can be found in all organisms. Moreover, a number of viral products exploit thioredoxin - thioredoxin reductase system for their replication.

HYPOXIA INDUCIBLE FACTOR-1 (HIF-1): STRUCTURE, REGULATION OF EXPRESSION, FUNCTION AND THE ROLE IN TUMOR PROGRESSION

One of the major components of the cellular response to oxygen deprivation is a heterodime- ric transcription factor - hypoxia inducible factor-1 (HIF-1). HIF-1 is constitutively produced and de- graded by the ubiquitin-proteasome system under normoxic conditions but becomes stabilized and transcriptionally active under hypoxic conditions. Hypoxia is one of the typical features of growing tumor and enhanced activity of HIF-1 observed in several different malignancies, is one of the most important factors responsible for activating pathways leading to tumor angiogenesis.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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