In aging population growing up rapidly causes of cancers are observed. Lost of immunological answer caused by DNA double-strand breakes, longer exposition to carcinogens, decreasing activity of DNA-repair system in aging cells, defects of supressor genes are caused carcinogenesis. DNA-defects of aging and cancer cells by hipermethylation GpC island of gene promoters are observed. Changes in extracellular matrix of aging and transformed cells are responsible forcell migration causing metastasis.