Skeletal muscle tissue is characterized by ability to regenerate in response to injury resulting for example from mechanical trauma, toxin or disease. The key role in this process is played by satellite cells localized in skeletal muscle. However, both under physiological and experimental conditions different types of stem cells originating either from skeletal muscle or other tissues can be also involved in regeneration. This raises the hope for potential use of stem cells in the therapy for skeletal muscles diseases, such as muscular dystrophies or spinal muscle atrophy. These pathologies are characterized by impairment of regeneration linked with depletion or reduction of endogenous population of satellite cells. Thus, transplantation of stem cells could improve regeneration of such muscle and, as a result, support their reconstruction. However, stem cells based therapy will be possible only after precise analysis of their features, especially their myogenic potential, i.e. the ability to differentiate into muscle cells and fibers. This review summarizes current state of knowledge concerning myogenic potential of different types of stem cells and indicates those that are likely to be used in a future as a source of cells transplanted during skeletal muscle therapy.