Mammalian ovary contains thousands of oocytes contained in the ovarian follicles przedantralnych . The vast majority of these bubbles are killed as a result of atresia . Thus, for example in cattle atresia is more than 99.9 % of the population bubbles. Ability to use bubbles by getting them in the very early stages of development and long-term in vitro culture would open almost unlimited source of female gametes and the potential gametotwórczy ovarian would be maximized .