Central nervous system (CNS) is seen as crucial in the organism and plays critical role in regulation and decision making processes on multisystem and behavioral level. The variety of diseases affecting CNS, and lack of effective therapy raises a question of chance of maintenance or recovery of the nervous function within the organism own forces. The presence of heterogenic population of stem (SCs) and progenitor cells in various regions of the retina and brain is well documented.

Achieving immunological tolerance is an important goal in the effort to reduce long-term morbidity and mortality in organ transplant recipients. The establishment of mixed chimerism through the transplantation of donor bone marrow cells is an experimental approach for tolerance induction with clinical potential. Permanent, robust donor-specific tolerance has been reliably achieved in various animals models of mixed chimerism.

An important source of vascularized organs and tissues for transplantation are heparinized donor organs ( HDN ) . The constantly growing number of downloads organ and the potential ease with which you can obtain from HDN marrow cells necessitated the need to develop effective methods for retrieving and securing them KKM , in terms of their use for transplantation . Up to now, the method of collecting bone marrow from organ donors who did not receive anticoagulant before harvesting bone marrow , were time-consuming, technically complicated and what that entails expensive.

STAT proteins ( called Signal Transducers and Activators of Transcription ) are a group of proteins involved in the transmission of information from the cell surface to the nucleus and activate gene transcription . They are activated in response to a number of cytokines , growth factors and hormones. Until now identified six STAT proteins : STAT1 , 2, 3 , 4, 5a/5b , 6 So far it was found that they play an important role in many physiopathological processes , starting from the immune responses, cell cycle regulation and malignant transformation of cells.