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GPR7 and GPR8 (G-protein-coupled Receptors) are two recently discovered and structural- ly related orphan receptors linked to protein G. They are present both in central nervous system and in peripheral organs. Recently, endogenous ligands of these receptors have been identified. One of them is a 29 amino acid residues long, uniquely modified with bromine and, thus, termed the neuropeptide B (NPB). The other, neuropeptide W (NPW), has been identified in two molecular forms of, respectively, 23 and 30 amino acids (NPW23 and NPW30). Amino acid sequence of NPW23 is identical with first 23 N-terminal amino acids of NPW30. Distribution of the gene expression within the brain suggests that NPB plays a role in feeding control, in control of the neuroendocrine axis, as well as in memory and learning processes. NPW, in turn, affects alimentation, stimulates prolactin secretion and regulates function of the hypothalamic-pituitary-adrenal axis.
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The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

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