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ATP cooperating with the P2 purinoceptors plays a role of neurotransmitter in the CNS. Both types of these purinoceptors (P2X and P2Y) are present in CNS. These receptors are found in all structures of the brain, but the P2X to P2Y ratio is characteristic for every structure. This ratio might change during the development and maturation of the brain structures. The special role in CNS is played by P2X purinoceptors, which are the ion channels characterized by low selectivity and fast transmission. On the other hand, the action of P2Y purinoceptors is mediated by the G proteins. The function of P2Y is connected to the activation of the intracellular second messengers. The sequence comparison of cloned P2 purinoceptors has revealed the differences not only between P2X and P2Y types, but also between members of this groups. The enzymes belonging to the E-NTPDase family play the special role in the ATP mediated neurotransmission. They break the signal and co-operate with 5'-nucleotidase in generation of other neurotransmitters. The antagonistic action of substrates and products of the chain of these enzymatic reactions suggests that the cell metabolism would depend on the [ATP]/[Ado] ratio.
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The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

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